Back to Search
Start Over
CRLF2 and IKZF1 abnormalities in childhood hematological malignancies other than B-cell Acute Lymphoblastic Leukemia.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2024 Jul 21, pp. 1-11. Date of Electronic Publication: 2024 Jul 21. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Rearrangements and overexpression of CRLF2 are hallmarks of poor outcomes in BCR::ABL1 -like B-ALL, and CRLF2 overexpression is a high-risk marker in T-ALL. However, CRLF2 alterations in pediatric hematologic malignancies other than B-ALL have not been reported. In this study, we analyzed the CRLF2 overexpression, rearrangements ( P2RY8::CRLF2 and IGH::CRLF2 ), activation (pSTAT5 and pERK), and the expression of dominant-negative IKZF1 isoforms (Ik6 and Ik8), implied in CRLF2 dysregulation, in 16 pediatric patients (AML, n = 9; T-ALL, n = 3; LBL, n = 2; HL, n = 1; cytopenia, n = 1). A high frequency of CRLF2 rearrangements and overexpression was found in the 16 patients: 28.6% (4/14) showed CRLF2 overexpression, 93.8% (15/16) were positive for CRLF2 total protein (cell-surface and/or cytoplasmic), while 62.5% (10/16) were positive for P2RY8::CRLF2 and 12.6% (2/16) for IGH::CRLF2 . In addition, 43.8% (7/16) expressed Ik6 and Ik8 isoforms. However, only a few patients were positive for the surrogate markers pSTAT5 (14.3%; 2/14) and pERK (21.4%; 3/14).
Details
- Language :
- English
- ISSN :
- 1029-2403
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 39034479
- Full Text :
- https://doi.org/10.1080/10428194.2024.2378817