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Neuroimaging for precision medicine in psychiatry.
- Source :
-
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Nov; Vol. 50 (1), pp. 246-257. Date of Electronic Publication: 2024 Jul 22. - Publication Year :
- 2024
-
Abstract
- Although the lifetime burden due to mental disorders is increasing, we lack tools for more precise diagnosing and treating prevalent and disabling disorders such as major depressive disorder. We lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional neuroimaging as a modality of measurement for precision psychiatry, focusing on major depressive and anxiety disorders. We begin by outlining evidence for the use of functional neuroimaging to stratify the heterogeneity of these disorders, based on underlying circuit dysfunction. We then review the current landscape of how functional neuroimaging-derived circuit predictors can predict treatment outcomes and clinical trajectories in depression and anxiety. Future directions for advancing clinically appliable neuroimaging measures are considered. We conclude by considering the opportunities and challenges of translating neuroimaging measures into practice. As an illustration, we highlight one approach for quantifying brain circuit function at an individual level, which could serve as a model for clinical translation.<br /> (© 2024. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
- Subjects :
- Humans
Depressive Disorder, Major diagnostic imaging
Depressive Disorder, Major therapy
Psychiatry methods
Psychiatry trends
Neuroimaging methods
Anxiety Disorders diagnostic imaging
Anxiety Disorders therapy
Functional Neuroimaging methods
Brain diagnostic imaging
Precision Medicine methods
Precision Medicine trends
Subjects
Details
- Language :
- English
- ISSN :
- 1740-634X
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 39039140
- Full Text :
- https://doi.org/10.1038/s41386-024-01917-z