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Neuroimaging for precision medicine in psychiatry.

Authors :
Williams LM
Whitfield Gabrieli S
Source :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Nov; Vol. 50 (1), pp. 246-257. Date of Electronic Publication: 2024 Jul 22.
Publication Year :
2024

Abstract

Although the lifetime burden due to mental disorders is increasing, we lack tools for more precise diagnosing and treating prevalent and disabling disorders such as major depressive disorder. We lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional neuroimaging as a modality of measurement for precision psychiatry, focusing on major depressive and anxiety disorders. We begin by outlining evidence for the use of functional neuroimaging to stratify the heterogeneity of these disorders, based on underlying circuit dysfunction. We then review the current landscape of how functional neuroimaging-derived circuit predictors can predict treatment outcomes and clinical trajectories in depression and anxiety. Future directions for advancing clinically appliable neuroimaging measures are considered. We conclude by considering the opportunities and challenges of translating neuroimaging measures into practice. As an illustration, we highlight one approach for quantifying brain circuit function at an individual level, which could serve as a model for clinical translation.<br /> (© 2024. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)

Details

Language :
English
ISSN :
1740-634X
Volume :
50
Issue :
1
Database :
MEDLINE
Journal :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Publication Type :
Academic Journal
Accession number :
39039140
Full Text :
https://doi.org/10.1038/s41386-024-01917-z