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The use of rh-NGF in the management of neurotrophic keratopathy.

The use of rh-NGF in the management of neurotrophic keratopathy.

Authors :
Roszkowska AM
Spinella R
Calderone A
Sindoni M
Wowra BH
Kozak M
Sajak-Hydzik K
AliĆ² J
Source :
Frontiers in ophthalmology [Front Ophthalmol (Lausanne)] 2024 Jul 08; Vol. 4, pp. 1408587. Date of Electronic Publication: 2024 Jul 08 (Print Publication: 2024).
Publication Year :
2024

Abstract

Neurotrophic keratitis or keratopathy (NK) is a degenerative corneal disease induced by impairment of the trigeminal nerve function. This condition may lead to persistent epithelial defects, corneal ulceration, and perforation. The diagnosis of NK requires a careful investigation of any ocular and systemic condition associated with the disease and ocular surface and corneal sensitivity examinations. In the past, several medical and surgical procedures were used to treat this condition with different clinical effectiveness. Cenegermin is a recombinant human nerve growth factor (rh-NGF) that supports corneal reinnervation. Different clinical trials have demonstrated the safety and efficacy of topical cenegermin in patients with moderate to severe neurotrophic keratitis. In this review, we report the literature on clinical results regarding the treatment of NK with cenegermin since its approval by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) in 2017 and 2018, respectively.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer IA declared a past co-authorship with the author JA to the handling editor.<br /> (Copyright © 2024 Roszkowska, Spinella, Calderone, Sindoni, Wowra, Kozak, Sajak-Hydzik and Aliò.)

Details

Language :
English
ISSN :
2674-0826
Volume :
4
Database :
MEDLINE
Journal :
Frontiers in ophthalmology
Publication Type :
Academic Journal
Accession number :
39040985
Full Text :
https://doi.org/10.3389/fopht.2024.1408587