Enzoology: understanding enzyme interactions and epistasis in the cell.

Authors :: Savinov A
Source :: Trends in biochemical sciences [Trends Biochem Sci] 2024 Oct; Vol. 49 (10), pp. 841-842. Date of Electronic Publication: 2024 Jul 23.
Publication Year :: 2024
Abstract: Recent work from Nguyen et al. unveils massively parallel measurements of epistatic interactions between two enzymes, dihydrofolate reductase and thymidylate synthase, in their natural cellular context. Almost 3000 mutations of DHFR in three TYMS backgrounds reveal a complex interaction network. The authors capture much of this complexity using a simple model.<br />Competing Interests: Declaration of interests The author declares no competing interests.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)