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Pulmonary delivery of magnolol-loaded nanostructured lipid carriers for COPD treatment.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2024 Sep 05; Vol. 662, pp. 124495. Date of Electronic Publication: 2024 Jul 23. - Publication Year :
- 2024
-
Abstract
- Chronic obstructive pulmonary disease (COPD) is a prevalent lung condition characterized by airflow obstruction, disability, and high mortality rates. Magnolol (MA), known for its anti-inflammatory and antioxidant properties, holds the potential for alleviating COPD symptoms. However, MA faces challenges like poor aqueous solubility and low bioavailability. Herein MA-loaded nanostructured lipid carriers (MA-NLC) were prepared using emulsification and solvent evaporation. These carriers exhibited a particle size of (19.67 ± 0.36) nm, a polydispersity index of (0.21 ± 0.01), and a zeta potential of (-5.18 ± 0.69) mV. The fine particle fraction of MA-NLC was (68.90 ± 0.07)%, indicating minimal lung irritation and enhanced safety. Pulmonary delivery of MA-NLC via nebulizer actively targeted the diseased lung tissues, facilitated slow release, and overcame the challenges of low oral absorption and bioavailability associated with MA. This formulation prolonged the residence time of MA and optimized its therapeutic effect in pulmonary tissues. Upon pulmonary administration, MA-NLC effectively regulated inflammatory and oxidative stress markers in COPD models, demonstrating its potential as a promising therapeutic platform for COPD management.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Inhalation
Male
Animals
Particle Size
Oxidative Stress drug effects
Antioxidants administration & dosage
Antioxidants chemistry
Antioxidants pharmacokinetics
Antioxidants pharmacology
Rats, Sprague-Dawley
Drug Liberation
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents pharmacokinetics
Anti-Inflammatory Agents pharmacology
Rats
Pulmonary Disease, Chronic Obstructive drug therapy
Lignans administration & dosage
Lignans pharmacokinetics
Lignans chemistry
Lignans pharmacology
Biphenyl Compounds administration & dosage
Biphenyl Compounds chemistry
Biphenyl Compounds pharmacokinetics
Drug Carriers chemistry
Lipids chemistry
Nanostructures administration & dosage
Nanostructures chemistry
Lung metabolism
Lung drug effects
Biological Availability
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 662
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 39053678
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2024.124495