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NIR-II light-powered core-shell prodrug nanomotors enhance cancer therapy through synergistic oxidative stress-photothermo modulation.
- Source :
-
Acta biomaterialia [Acta Biomater] 2024 Sep 01; Vol. 185, pp. 396-409. Date of Electronic Publication: 2024 Jul 23. - Publication Year :
- 2024
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Abstract
- Near-infrared-II (NIR-II) photothermal therapy is emerging as a cutting-edge modality for tumor ablation due to its good biosafety, high penetration ability and spatiotemporal controllability. Despite efforts, establishing a link between cellular metabolic regulation and photothermal performance is still promising in synergistic cancer therapy. Herein, we developed a core-shell semiconducting polymer@metal-phenolic network (SP@GFP) nanomotor by assembling diphenol-terminated cisplatin prodrug ligand (cPt-DA) and iron (III) (Fe <superscript>3+</superscript> ) through metal coordination on SP particles in the presence of GOx and DSPE-PEG-cRGD, for NIR-II-propelled self-propulsion and synergistic cancer therapy. Remotely driving the SP@GFP nanomotor with an NIR-II laser through a thermophoresis mechanism would allow for in-depth penetration and accumulation. The synergistic photothermal effect and continuous Fe <superscript>2+</superscript> -mediated ROS generation of SP@GFP nanomotor could activate photothermal, chemotherapeutic effects and ferroptosis pathway for cancer cells through reshaping cellular metabolic pathways (HSP and GPX4). By combining the concepts of chemotherapeutic prodrugs, catalytic ROS generation, photothermal response and cellular metabolic regulation, the NIR-II laser-controlled core-shell SP@GFP nanomotor displayed improved outcomes for enhanced cancer therapy through synergistic oxidative stress-photothermo modulation. STATEMENT OF SIGNIFICANCE.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Animals
Mice
Neoplasms pathology
Neoplasms therapy
Neoplasms drug therapy
Neoplasms metabolism
Nanoparticles chemistry
Photothermal Therapy
Cell Line, Tumor
Mice, Inbred BALB C
Reactive Oxygen Species metabolism
Female
Mice, Nude
Prodrugs pharmacology
Prodrugs chemistry
Oxidative Stress drug effects
Infrared Rays
Subjects
Details
- Language :
- English
- ISSN :
- 1878-7568
- Volume :
- 185
- Database :
- MEDLINE
- Journal :
- Acta biomaterialia
- Publication Type :
- Academic Journal
- Accession number :
- 39053815
- Full Text :
- https://doi.org/10.1016/j.actbio.2024.07.030