An evaluation of the All of Us Research Program database to examine cumulative stress.

Objectives: To evaluate the NIH All of Us Research Program database as a potential data source for studying allostatic load and stress among adults in the United States (US).
Materials and Methods: We evaluated the All of Us database to determine sample size significance for original-10 allostatic load biomarkers, Allostatic Load Index-5 (ALI-5), Allostatic Load Five, and Cohen's Perceived Stress Scale (PSS). We conducted a priori, post hoc, and sensitivity power analyses to determine sample sizes for conducting null hypothesis significance tests.
Results: The maximum number of responses available for each measure is 21 participants for the original-10 allostatic load biomarkers, 150 for the ALI-5, 22 476 for Allostatic Load Five, and n = 90 583 for the PSS.
Discussion: The NIH All of Us Research Program is well-suited for studying allostatic load using the Allostatic Load Five and psychological stress using PSS.
Conclusion: Improving biomarker data collection in All of Us will facilitate more nuanced examinations of allostatic load among US adults.
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