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Targeting the sulfur-containing amino acid pathway in leukemia.
- Source :
-
Amino acids [Amino Acids] 2024 Jul 26; Vol. 56 (1), pp. 47. Date of Electronic Publication: 2024 Jul 26. - Publication Year :
- 2024
-
Abstract
- sulfur-containing amino acids have been reported to patriciate in gene regulation, DNA methylation, protein synthesis and other physiological or pathological processes. In recent years, metabolism-related molecules of sulfur-containing amino acids affecting the occurrence, development and treatment of tumors have been implicated in various disorders, especially in leukemia. Here, we summarize current knowledge on the sulfur-containing amino acid metabolism pathway in leukemia and examine ongoing efforts to target this pathway, including treatment strategies targeting (a) sulfur-containing amino acids, (b) metabolites of sulfur-containing amino acids, and (c) enzymes and cofactors related to sulfur-containing amino acid metabolism in leukemia. Future leukemia therapy will likely involve innovative strategies targeting the sulfur-containing amino acid metabolism pathway.<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1438-2199
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Amino acids
- Publication Type :
- Academic Journal
- Accession number :
- 39060524
- Full Text :
- https://doi.org/10.1007/s00726-024-03402-9