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Electrochemical Impedance Spectroscopy in the Determination of the Dielectric Properties of Tau-441 Protein for Dielectrophoresis Response Prediction.

Authors :
Shee Da En Z
Mhd Noor EE
Ahmed Kayani A
Hussin MH
Farrukh Baig M
Source :
Bioengineering (Basel, Switzerland) [Bioengineering (Basel)] 2024 Jul 10; Vol. 11 (7). Date of Electronic Publication: 2024 Jul 10.
Publication Year :
2024

Abstract

This study employs electrochemical impedance spectroscopy (EIS) to probe the behavior of Tau-441 protein, a key component implicated in Alzheimer's disease. Through meticulous experimentation and analysis, the impedance of Tau-441 protein suspension revealed a conductivity peak value of 1.02 S/m. The study demonstrates a high level of specificity and selectivity, particularly within the challenging nanomolar concentration range. Additionally, the EIS method enabled the prediction of Tau-441 protein's dielectrophoresis (DEP) response and the determination of the associated frequency range of 1 kHz to 1 MHz. These findings contribute to advancing our understanding of the molecular intricacies surrounding Tau-441 and hold promise for unraveling implications related to Alzheimer's disease. This study establishes a robust foundation for future research on neurodegenerative disease and biosciences, offering valuable insights into the electrochemical dynamics of Tau-441 protein.

Details

Language :
English
ISSN :
2306-5354
Volume :
11
Issue :
7
Database :
MEDLINE
Journal :
Bioengineering (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
39061780
Full Text :
https://doi.org/10.3390/bioengineering11070698