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Age and gender differences of normative values of spleen diffusion MRI parameters.
- Source :
-
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin [Rofo] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- This study investigates age and gender differences of normative values of spleen diffusion MRI parameters.We recruited 124 volunteers with MRI conducted at 1.5T. Diffusion imaging had b-values of 0, 2, 4, 7, 10, 15, 20, 30, 46, 60, 72, 100, 150, 200, 400, 600 s/mm <superscript>2</superscript> . ADC, IVIM-Dslow, IVIM-PF, IVIM-Dfast, and DDVD (diffusion-derived vessel density) were computed. DDVD is the signal difference between the b=0 s/mm <superscript>2</superscript> image and b=2, 4 s/mm <superscript>2</superscript> image. Only images without apparent artifacts and with good curving fitting were included in the analysis. Finally, 34 females (age: 20-71 years) and 69 males (22-70 years) were measured with ADC; 20 females (20-71 years) and 48 males (22-67 years) were measured with IVIM; 32 females (20-71 years) and 65 males (22-70 years) were measured with DDVD parameter.An age-related decrease in ADC was noted for females, while such a trend was not noted for males. A very high level of heterogeneity was noted for the data for the males, with the highest ADC value being 1.710 × 10 <superscript>-3</superscript> mm <superscript>2</superscript> /s and the lowest ADC value being 0.705 × 10 <superscript>-3</superscript> mm <superscript>2</superscript> /s when b=0 and 600 s/mm <superscript>2</superscript> were used for ADC calculation. A male-female data comparison did not show a statistically significant difference between the ADC median value. However, ADCs > 1.3 × 10 <superscript>-3</superscript> mm <superscript>2</superscript> /s were only seen among males. A very high level of heterogeneity was also noted for males' Dslow, with the highest value being 1.468 × 10 <superscript>-3</superscript> mm <superscript>2</superscript> /s and the lowest value being 0.600 × 10 <superscript>-3</superscript> mm <superscript>2</superscript> /s. Both PF and Dfast demonstrated a trend of age-related increase for older subjects. PF values were higher among males than females. However, no difference was noted for Dfast between males and females. DDVD did not show an age-related trend both for females and males. No difference was noted in DDVD values between males and females.Interpreting normal spleen diffusion MRI parameters should consider age and gender factors. · An age-related decrease in spleen ADC and IVIM-Dslow was seen for healthy females.. · There is a high level of heterogeneity for spleen ADC and IVIM-Dslow data for healthy males.. · IVIM modelled perfusion fraction and Dfast demonstrate an artificial trend of age-related increase for older subjects.. · Vessel density measured on diffusion imaging does not show an age-related trend.. · Yu W, Ma FZ, Huang H et al. Age and gender differences of normative values of spleen diffusion MRI parameters. Fortschr Röntgenstr 2024; DOI 10.1055/a-2357-9741.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1438-9010
- Database :
- MEDLINE
- Journal :
- RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
- Publication Type :
- Academic Journal
- Accession number :
- 39079680
- Full Text :
- https://doi.org/10.1055/a-2357-9741