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Childhood obesity is associated with a high degree of metabolic disturbance in children from Brazilian semi-arid region.
- Source :
-
Scientific reports [Sci Rep] 2024 Jul 30; Vol. 14 (1), pp. 17569. Date of Electronic Publication: 2024 Jul 30. - Publication Year :
- 2024
-
Abstract
- Projected to impact 310 million children by the next decade, childhood obesity is linked to serious health issues like metabolic disturbance and cardiovascular diseases. This study introduces a novel approach for the integrated assessment of inflammatory, glycemic and lipid disorders in obese children in resources-limited settings and also identifies key factors contributing to these changes. Conducting a cross-sectional analysis of 231 children aged 5-12 years from public schools in Brazil's semi-arid region, the research involved collecting medical history, anthropometric measurements, and blood samples to analyze glycemic and lipid profiles, along with C-reactive protein levels. We used an adapted the Molecular Degree of Perturbation model to analyze deviations in metabolic markers from a healthy control group. Statistical analyses included Mann-Whitney and Fisher exact tests, backward logistic regression, and hierarchical cluster analysis. The study identified a direct and independent association between elevated Metabolic Disturbance Degree and both overweight and obesity in children, with significant differences in CRP, Triglycerides, and HDL levels noted between obese and healthy-weight groups. The findings highlight the critical need for early detection and comprehensive understanding of obesity-related changes to mitigate the severe health risks associated with childhood obesity.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Child
Brazil epidemiology
Male
Female
Child, Preschool
Cross-Sectional Studies
C-Reactive Protein metabolism
C-Reactive Protein analysis
Metabolic Diseases blood
Metabolic Diseases epidemiology
Metabolic Diseases etiology
Biomarkers blood
Triglycerides blood
Pediatric Obesity blood
Pediatric Obesity epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39080451
- Full Text :
- https://doi.org/10.1038/s41598-024-68661-8