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Childhood obesity is associated with a high degree of metabolic disturbance in children from Brazilian semi-arid region.

Authors :
Ferreira IBB
Gomes AN
Almeida IBC
Fernandes MD
Coutinho LF
Lago R
Menezes CA
Vianna NA
Oliveira RR
Fukutani ER
Menezes RC
Ladeia AM
Andrade BB
Source :
Scientific reports [Sci Rep] 2024 Jul 30; Vol. 14 (1), pp. 17569. Date of Electronic Publication: 2024 Jul 30.
Publication Year :
2024

Abstract

Projected to impact 310 million children by the next decade, childhood obesity is linked to serious health issues like metabolic disturbance and cardiovascular diseases. This study introduces a novel approach for the integrated assessment of inflammatory, glycemic and lipid disorders in obese children in resources-limited settings and also identifies key factors contributing to these changes. Conducting a cross-sectional analysis of 231 children aged 5-12 years from public schools in Brazil's semi-arid region, the research involved collecting medical history, anthropometric measurements, and blood samples to analyze glycemic and lipid profiles, along with C-reactive protein levels. We used an adapted the Molecular Degree of Perturbation model to analyze deviations in metabolic markers from a healthy control group. Statistical analyses included Mann-Whitney and Fisher exact tests, backward logistic regression, and hierarchical cluster analysis. The study identified a direct and independent association between elevated Metabolic Disturbance Degree and both overweight and obesity in children, with significant differences in CRP, Triglycerides, and HDL levels noted between obese and healthy-weight groups. The findings highlight the critical need for early detection and comprehensive understanding of obesity-related changes to mitigate the severe health risks associated with childhood obesity.<br /> (© 2024. The Author(s).)

Details

Language :
English
ISSN :
2045-2322
Volume :
14
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
39080451
Full Text :
https://doi.org/10.1038/s41598-024-68661-8