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The efficacy and safety of difelikefalin for pruritus in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials.
- Source :
-
Renal failure [Ren Fail] 2024 Dec; Vol. 46 (2), pp. 2384590. Date of Electronic Publication: 2024 Aug 01. - Publication Year :
- 2024
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Abstract
- Background: Chronic kidney disease-associated pruritus (CKD-ap) is a common complication that negatively affects the quality of life. Difelikefalin has emerged as a novel FDA-approved drug to manage CKD-ap. This systematic review and meta-analysis will assess the efficacy and safety of Difelikefalin versus placebo to manage CKD-ap.<br />Methods: PubMed, Scopus, WOS, Central, and Embase were systematically searched until November 2023. RevMan was used to perform meta-analysis. Quality assessment was conducted using the Cochrane RoB 2.0 tool. Results were reported as risk ratio (RR) and mean difference (MD) with a 95% confidence interval (CI). PROSPERO ID: (CRD42023485979).<br />Results: Five RCTs with a total of 896 participants were included. Difelikefalin significantly decreased the weekly mean WI-NRS score (MD: -0.99 [-1.22, -0.75], p ˂ .00001), 5-D itch scale total score (MD: -1.51 [-2.26, -0.76], p > .0001), and Skindex-10 total score (MD: -7.39 [-12.51, -2.28], p = .005), but showed significantly higher adverse events (RR: 1.26 [1.03, 1.55], p = .03), versus placebo. However, there was no significant difference between both groups in serious adverse events (RR: 1.42 [0.78, 2.57], p = .25) or death (RR: 0.81 [0.19, 3.34], p = .77).<br />Conclusion: Difelikefalin appears to be a promising agent for the management of CKD-induced pruritus in patients with end-stage renal disease. However, evidence is still underpowered due to the paucity of the current data; therefore, more robust RCTs are required to confirm the benefit of Difelikefalin.
- Subjects :
- Humans
Treatment Outcome
Antipruritics therapeutic use
Antipruritics adverse effects
Piperidines
Pruritus drug therapy
Pruritus etiology
Randomized Controlled Trials as Topic
Renal Dialysis adverse effects
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic therapy
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1525-6049
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Renal failure
- Publication Type :
- Academic Journal
- Accession number :
- 39091079
- Full Text :
- https://doi.org/10.1080/0886022X.2024.2384590