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Stearoyl-CoA desaturase 1 is targeted by EBV-encoded miR-BART20-5p and regulates cell autophagy, proliferation, and migration in EBV-associated gastric cancer.
- Source :
-
Virus genes [Virus Genes] 2024 Oct; Vol. 60 (5), pp. 464-474. Date of Electronic Publication: 2024 Aug 03. - Publication Year :
- 2024
-
Abstract
- Epstein-Barr virus (EBV) is the first human oncogenic virus known to express microRNAs (miRNAs), which are closely associated with the development of various tumors, including nasopharyngeal and gastric cancers. Stearoyl-CoA Desaturase 1 (SCD1) is a key enzyme in fatty acid synthesis, highly expressed in numerous tumors, promoting tumor growth and metastasis, making it a potential therapeutic target. In this study, we found that SCD1 expression in EBV-associated gastric cancer (EBVaGC) was significantly lower than in EBV-negative gastric cancer (EBVnGC) at both cellular and tissue levels. In addition, EBV-miR-BART20-5p targets the 3'-UTR of SCD1, downregulating its expression. Moreover, overexpression of SCD1 in EBVaGC cells promoted cell migration and proliferation while inhibiting autophagy. These results suggest that EBV-encoded miRNA-BART20-5p may contribute to EBVaGC progression by targeting SCD1.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Cell Line, Tumor
Epstein-Barr Virus Infections virology
Epstein-Barr Virus Infections genetics
Gene Expression Regulation, Neoplastic
3' Untranslated Regions genetics
RNA, Viral genetics
Stomach Neoplasms virology
Stomach Neoplasms genetics
Stomach Neoplasms pathology
MicroRNAs genetics
Stearoyl-CoA Desaturase genetics
Autophagy genetics
Cell Movement genetics
Herpesvirus 4, Human genetics
Cell Proliferation genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1572-994X
- Volume :
- 60
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Virus genes
- Publication Type :
- Academic Journal
- Accession number :
- 39096336
- Full Text :
- https://doi.org/10.1007/s11262-024-02094-3