Back to Search
Start Over
Biofabrication of aminated nanocellulose reinforced polyvinyl alcohol/chitosan nanofibrous scaffold for sustained release of diltiazem hydrochloride.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 277 (Pt 3), pp. 134395. Date of Electronic Publication: 2024 Aug 05. - Publication Year :
- 2024
-
Abstract
- In the modern environment conscious era, there has been a huge demand for the effective green method to fabricate biomaterials for sustained transdermal release of diltiazem hydrochloride to treat hypertension and cardiac failure. In this vein, the present study explores the amination of waste jute sourced nanocellulose (ANC) and its effect as a reinforcing filler to design electrospun polyvinyl alcohol (PVA)/chitosan based polymeric nanofibrous scaffold for drug delivery. The characterization results of FTIR (Fourier Transform Infrared Spectroscopy) confirm the successful chemical modification of nanocellulose (NCC). SEM (Scanning Electron Microscopy) results indicate the morphological modifications in ANC due to grafting. ANC enhances the mechanical properties of scaffold and sustains the release of the loaded drug to 67.89±3.39% as compared to the pure PVA/chitosan scaffold of 92.63±4.63% over a period of 72 h as shown by the results of in-vitro drug release study. Moreover, the incorporation of 0.5 % ANC improves the anti-bacterial activity against both gram-positive (97.4±4.87%, reduction in viable cells count) and gram-negative bacteria (98.5±4.93%, reduction in viable cells count). Further, the skin irritation and MTT assay authenticate the biocompatibility of the developed scaffold. The overall findings hence prove the efficacy of the engineered scaffold as a potential transdermal patch for sustained drug delivery applications.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Animals
Spectroscopy, Fourier Transform Infrared
Drug Carriers chemistry
Biocompatible Materials chemistry
Tissue Scaffolds chemistry
Chitosan chemistry
Polyvinyl Alcohol chemistry
Nanofibers chemistry
Cellulose chemistry
Diltiazem chemistry
Diltiazem pharmacology
Delayed-Action Preparations
Drug Liberation
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 277
- Issue :
- Pt 3
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 39098668
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.134395