Back to Search
Start Over
Identification of the inflammatory cells in the central nervous system of patients with adrenoleukodystrophy.
- Source :
-
Annals of neurology [Ann Neurol] 1985 Dec; Vol. 18 (6), pp. 660-4. - Publication Year :
- 1985
-
Abstract
- Adrenoleukodystrophy is a disorder of long-chain fatty acid metabolism associated with adrenal cortical insufficiency and central nervous system demyelination. The central nervous system disease is unusual in that it is abrupt in onset and accompanied by a considerable infiltration of mononuclear inflammatory cells. To determine the nature of these inflammatory cells, immunocytochemical staining was carried out on the mononuclear cells in the brain and cerebrospinal fluid of patients with adrenoleukodystrophy. Monoclonal antibodies to T lymphocytes (T11), the helper/inducer (T4) and cytotoxic/suppressor (T8) subsets of T lymphocytes, B lymphocytes (B1), and monocyte/macrophages (M1 or esterase) were used. Mononuclear cells in the perivascular cuffs of autopsy material from 4 patients were, on average, 59% T cells, 34% T4 cells, 16% T8 cells, 24% B cells, and 11% monocyte/macrophages. Cerebrospinal fluid from 8 of 10 patients had increased IgG concentrations. Mononuclear cells in the cerebrospinal fluid of 6 patients with active disease were, on average, 61% T cells, 40% T4 cells, 16% T8 cells, 3% B cells, and 18% monocyte/macrophages. This distribution of cells is similar to that found in the central nervous system during a cellular immune response and suggests the possibility that one component of this disease is immunologically mediated.
- Subjects :
- Adolescent
Adrenoleukodystrophy immunology
Adult
B-Lymphocytes pathology
Child
Child, Preschool
Esterases metabolism
Humans
Immunoenzyme Techniques
Macrophages pathology
Monocytes pathology
T-Lymphocytes pathology
Adrenoleukodystrophy pathology
Brain pathology
Cerebrospinal Fluid cytology
Diffuse Cerebral Sclerosis of Schilder pathology
Leukocytes pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0364-5134
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 3909937
- Full Text :
- https://doi.org/10.1002/ana.410180606