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Oral amoxycillin, an alternative treatment for neurosyphilis.

Authors :
Morrison RE
Harrison SM
Tramont EC
Source :
Genitourinary medicine [Genitourin Med] 1985 Dec; Vol. 61 (6), pp. 359-62.
Publication Year :
1985

Abstract

A serum amoxycillin concentration of 0.11 g/l was established as being treponemicidal in a rabbit model with orchitis. Seventeen patients treated with amoxycillin 2 g by mouth three times a day plus 500 mg probenecid twice a day attained treponemicidal CSF amoxycillin concentrations. Thus amoxycillin by mouth offers an effective alternative method for treating patients with neurosyphilis.

Subjects

Subjects :
Administration, Oral
Amoxicillin cerebrospinal fluid
Amoxicillin therapeutic use
Animals
Disease Models, Animal
Female
Humans
Male
Probenecid therapeutic use
Rabbits
Treponema pallidum drug effects
Amoxicillin administration & dosage
Neurosyphilis drug therapy

Details

Language :
English
ISSN :
0266-4348
Volume :
61
Issue :
6
Database :
MEDLINE
Journal :
Genitourinary medicine
Publication Type :
Academic Journal
Accession number :
3910544
Full Text :
https://doi.org/10.1136/sti.61.6.359
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