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HFIP-Mediated Dual C(Ar)-Alkylation Process towards the Regioselective Synthesis of Triarylmethanes (TRAMs).
- Source :
-
Chemistry, an Asian journal [Chem Asian J] 2024 Aug 07, pp. e202400635. Date of Electronic Publication: 2024 Aug 07. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- The distinct roles of different chemical species are essential for the discovery of novel chemical transformations in organic synthesis. Here, we have designed a potential strategy for the synthesis of triarylmethanes (TRAMs) using the dual C(aryl)-alkylation process. This protocol was influenced by 1,1,1,3,3,3-hexafluoro isopropanol (HFIP) as a pivotal reagent and proceeds through the selective para C-H functionalization method. The described approach has been proven to be highly efficient in terms of substrate scope with excellent functional group tolerance and gram scale synthesis of the desired product with 90% yield. The recyclability and reusability of HFIP has enhanced the feasibility of this protocol towards the sustainable synthesis of TRAMs.<br /> (© 2024 Wiley‐VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1861-471X
- Database :
- MEDLINE
- Journal :
- Chemistry, an Asian journal
- Publication Type :
- Academic Journal
- Accession number :
- 39109591
- Full Text :
- https://doi.org/10.1002/asia.202400635