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Experimental and In Silico Comparative Study of Physicochemical Properties and Antimicrobial Activity of Carboxylate Ionic Liquids.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2024 Aug 02; Vol. 29 (15). Date of Electronic Publication: 2024 Aug 02. - Publication Year :
- 2024
-
Abstract
- The COVID-19 pandemic highlighted the need to create and study new substances with improved lipophilicity and antimicrobial properties, such as ionic liquids (ILs), with easily tunable physicochemical properties. Most ILs possess strong antibacterial effects, but ILs containing the imidazolium cation are even more effective than the positive control. Thus, in this study, three ionic liquids with 1-butyl-3-methylimidazolium cation and various carboxylate anions (phenylacetate, benzoate, and 4-methoxyphenylacetate) were synthesized and fully characterized. The interactions between the cations and anions were discussed based on the experimental density, viscosity, and electrical conductivity. From the measured electrical conductivity and viscosity, the Walden plot is constructed and ionicity of the studied ILs is discussed. The similarities and dissimilarities among the studied ILs and their physicochemical properties are analyzed by applying the hierarchical cluster analysis and in silico calculated properties. The antimicrobial activity of the studied ionic liquids is tested on two bacterial ( E. coli and P. aeruginosa ) and three fungi ( P. verrucosum , A. flavus , and A. parasiticus ) strains, finding that they showed improved antimicrobial activity compared to the individual components.
- Subjects :
- Viscosity
Imidazoles chemistry
Imidazoles pharmacology
Imidazoles chemical synthesis
Electric Conductivity
Microbial Sensitivity Tests
Computer Simulation
Escherichia coli drug effects
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents chemical synthesis
COVID-19 virology
Ionic Liquids chemistry
Ionic Liquids pharmacology
Anti-Infective Agents pharmacology
Anti-Infective Agents chemistry
Anti-Infective Agents chemical synthesis
Carboxylic Acids chemistry
Carboxylic Acids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 29
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 39125070
- Full Text :
- https://doi.org/10.3390/molecules29153668