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Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 Jul 29; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 29. - Publication Year :
- 2024
-
Abstract
- Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 39125829
- Full Text :
- https://doi.org/10.3390/ijms25158259