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Targeting glucosyltransferases to combat dental caries: Current perspectives and future prospects.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 2), pp. 134645. Date of Electronic Publication: 2024 Aug 10. - Publication Year :
- 2024
-
Abstract
- The emergence of antimicrobial resistance within bacterial communities poses formidable challenges to existing therapeutic strategies aimed at mitigating biofilm-mediated infections. Recent advancements in this domain have spurred the development of targeted antimicrobial agents, designed to selectively eradicate the primary etiological agents while preserving the beneficial microbial diversity of the oral cavity. Targeting glucosyltransferases (GTFs), which play crucial roles in dental biofilm formation, offers a precise strategy to inhibit extracellular polysaccharide synthesis without compromising oral microbiota. This review article delves into the intricate mechanisms underlying dental caries, with a specific focus on the role of GTFs, enzymes produced by S. mutans. It further provides an overview of current research on GTF inhibitors, exploring their mechanisms of action, efficacy, and potential applications in clinical practice. Furthermore, it discusses the challenges and opportunities in the development of novel GTF inhibitors, emphasizing the need for innovative approaches to combat biofilm-mediated oral diseases effectively.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Streptococcus mutans drug effects
Streptococcus mutans enzymology
Anti-Bacterial Agents therapeutic use
Anti-Bacterial Agents pharmacology
Enzyme Inhibitors therapeutic use
Enzyme Inhibitors pharmacology
Animals
Dental Caries microbiology
Dental Caries drug therapy
Dental Caries prevention & control
Glucosyltransferases antagonists & inhibitors
Glucosyltransferases metabolism
Biofilms drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 278
- Issue :
- Pt 2
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 39128764
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.134645