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Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2024 Oct; Vol. 310 (4), pp. 1895-1903. Date of Electronic Publication: 2024 Aug 14. - Publication Year :
- 2024
-
Abstract
- Purpose: Myo-inositol (MI) is an insulin-sensitizing dietary supplement, enhancing the transfer of glucose into the cell. Gestational diabetes mellitus (GDM) is characterized by abnormal glucose tolerance, which is associated with elevated insulin resistance. The present study aimed to assess the effect of MI supplementation during pregnancy on the incidence of GDM.<br />Methods: We performed a single-center, open-label, randomized controlled trial. A cohort of 200 pregnant women at 11-13 <superscript>+6</superscript> weeks of gestation were randomly assigned in two groups: MI group (n = 100) and control group (n = 100). The MI group received MI and folic acid (4000 mg MI and 400 mcg folic acid daily), while the control group received folic acid alone (400 mcg folic acid daily) until 26-28 weeks of gestation, when the 75 g Oral Glucose Tolerance Test (OGTT) was performed for the diagnosis of GDM. Clinical and metabolic outcomes were assessed.<br />Results: The incidence of GDM was significantly higher in the MI group (14.9%) compared to the control group (28.5%) (P = 0.024). Women treated with MI had significantly lower OGTT glucose values, than those not treated with MI (P < 0.001). The insulin resistance as assessed by HOMA-IR was significantly lower in the MI group versus control (P = 0.045). Furthermore, MI group had significantly higher insulin sensitivity as measured by the Matsuda Index, compared to the control group (P = 0.037).<br />Conclusion: MI supplementation seems to be an effective option to improve the glycemic control of pregnant women and prevent the onset of GDM.<br />Trial Registration: ISRCTN registry: ISRCTN16142533. Registered 09 March 2017.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Humans
Female
Pregnancy
Adult
Blood Glucose metabolism
Blood Glucose drug effects
Incidence
Vitamin B Complex therapeutic use
Vitamin B Complex administration & dosage
Diabetes, Gestational prevention & control
Diabetes, Gestational blood
Inositol therapeutic use
Inositol administration & dosage
Insulin Resistance
Dietary Supplements
Glucose Tolerance Test
Folic Acid administration & dosage
Folic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 310
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 39141124
- Full Text :
- https://doi.org/10.1007/s00404-024-07618-8