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The influence of the interventionalist's sex on the outcome and complications of transbronchial lung cryobiopsy.
- Source :
-
Respiratory medicine [Respir Med] 2024 Nov; Vol. 233, pp. 107772. Date of Electronic Publication: 2024 Aug 13. - Publication Year :
- 2024
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Abstract
- Background: To date there are no data on sex aspects evaluating outcomes of interventional pneumology (IP). Our aim was to investigate sex differences in transbronchial lung cryobiopsy (TBLC) outcomes in the diagnosis of interstitial lung disease (ILD).<br />Methods: All consecutive (TBLC)s performed for ILD evaluation between Nov 17 and Dec 21 at a tertiary referral center for ILDs and IP were analyzed. The indication for the procedure was determined by a multidisciplinary discussion (MDD). Final results including bronchoalveolar lavage (BAL) and histology were discussed in a 2nd MDD and outcomes and procedure related complications were assessed.<br />Results: TBLC was performed in 406 patients (38.4 % female/67.8 years/FVC 76.8 %). Among 32 interventionalists, 16 females performed 53 % of interventions. Females had longer procedure times (29.9 vs. 26.6 min, p = 0.046), used fluoroscopy more often (76.7 vs. 50.3 %, p < 0.001) and obtained more samples (3.6 vs. 3.2, p = 0.021) than their male counterparts. No difference was found for major bleeding or pneumothorax. MDD was able to conclude on a diagnosis in 88.4 % of interventions performed by women and in 78.5 % performed by men (p = 0.010). In a multivariate analysis, female gender (OR 1.93) and lower FVC% values (OR 0.98) were significantly associated with diagnostic yield, whereas the number of biopsies, professional experience, use of fluoroscopy or antiplatelet drugs were not relevant.<br />Conclusion: The results of this study strengthen the role of women in endoscopy and may help to motivate women to pursue a career in IP.<br />Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: FCT received research funding from Octapharma Pharmazeutika Produktionsgeselltschaft m.b.H. to conduct this study; the funder had no influence on the evaluation and interpretation of the data. FCT has received honoraria for lectures from Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Grifols, Novartis, CSL Behring. She participates in an Advisory Board for CSL Behring, GlaxoSmithKline and Boehringer Ingelheim, outside the submitted work. RE reports honoraria or payment for lectures and presentations from Broncus, Olympus, Pentax, Pulmonx, Astra Zeneca. He joins the data safety monitoring board for Intuitive Surgical Inc, outside the submitted work. FJFH reports Research Support from Olympus Medical, Pulmonx, Broncus, Uptake Medical, Roche Diagnostics, BMBF, DFG, EU, Klaus-Tschira Stiftung, BMG; Lecturing honoraria from Pulmonx, Uptake Medical, Roche Diagnostics, Astra Zeneca, Boehringer Ingelheim, Novartis, Berlin Chemie, Chiesi, Medupdate, Erbe, GSK and consulting activities for Olympus Medical, Pulmonx, Broncus – Uptake Medical, Roche Diagnostics, Astra Zeneca, J&J, Karger, LÄK, Boston Scientific, Dinova, Nanovation, Free Flow Medical, Erbe, outside the submitted work. KKo. Has received honoraria for lectures from Berlin-Chemie, Astra Zeneca and Boston Scientific, outside the submitted work. KKa has received honoraria for lectures form Berlin-Chemie, Astra Zeneca, Boehringer Ingelheim, Insmed, outside the submitted work. JDM, CA, MS, ME, MP, MK have nothing to disclose.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Humans
Female
Male
Aged
Biopsy adverse effects
Biopsy methods
Middle Aged
Sex Factors
Cryosurgery methods
Cryosurgery adverse effects
Bronchoalveolar Lavage methods
Bronchoalveolar Lavage adverse effects
Fluoroscopy
Pneumothorax etiology
Hemorrhage etiology
Retrospective Studies
Lung Diseases, Interstitial pathology
Lung Diseases, Interstitial diagnosis
Bronchoscopy methods
Bronchoscopy adverse effects
Lung pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3064
- Volume :
- 233
- Database :
- MEDLINE
- Journal :
- Respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39142597
- Full Text :
- https://doi.org/10.1016/j.rmed.2024.107772