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Evaluation of autoimmune liver disease antibodies in hepatitis patients.
- Source :
-
PloS one [PLoS One] 2024 Aug 20; Vol. 19 (8), pp. e0307285. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Background/aims: Autoimmune hepatitis (AIH) is characterized by the presence of auto-antibodies and high blood immunoglobulin G (IgG) levels. In this study, the line immunoassay (LIA) was designed to assess various autoantibodies.<br />Methods: In total, 1371 patients who underwent autoimmune liver disease antibody testing between July 2019 and November 2022 were enrolled. Autoantibodies including antinuclear antibody (ANA) and anti-mitochondrial antibody (AMA) were tested, and clinical data were collected. Statistical analyses were performed by categorizing the data based on diagnosis and IgG quantification separately. A scoring system was applied to identify individuals with AIH. Patients were also classified into the AIH and non-AIH groups.<br />Results: The positivity rate for ANA was 80.2% in the AIH group. The IgG-high group had a high likelihood of the presence of detectable autoantibodies, with anti-Ro-52 being the most frequently detected antibody using LIA. The "Consider AIH" and "AMA" groups had 3-4 times more patients in the IgG-high group than in the "Not Considered" group.<br />Conclusions: Among autoantibodies, the prevalence of ANA was the highest. As per LIA results, anti-Ro-52 was the most prevalent. AIH cannot be diagnosed based on IgG levels alone and must be distinguished via autoantibody testing. Therefore, extensive testing, including autoantibodies, IgG, ANA, and liver enzyme levels, will help accurately diagnose AIH.<br />Competing Interests: The authors have declared that no competing interests exist.<br /> (Copyright: © 2024 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Aged
Hepatitis, Autoimmune immunology
Hepatitis, Autoimmune blood
Hepatitis, Autoimmune diagnosis
Autoantibodies blood
Autoantibodies immunology
Immunoglobulin G blood
Immunoglobulin G immunology
Antibodies, Antinuclear blood
Antibodies, Antinuclear immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 39163317
- Full Text :
- https://doi.org/10.1371/journal.pone.0307285