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Chemoarchitectural signatures of subcortical shape alterations in generalized epilepsy.
- Source :
-
Communications biology [Commun Biol] 2024 Aug 20; Vol. 7 (1), pp. 1019. Date of Electronic Publication: 2024 Aug 20. - Publication Year :
- 2024
-
Abstract
- Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical structures are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet to be comprehensively investigated. Furthermore, the relationships between macroscale morphological disturbances and microscale molecular chemoarchitectures are unclear. High-resolution structural images were acquired from patients with GGE (n = 97) and sex- and age-matched healthy controls (HCs, n = 184). Individual measurements of surface shape features (thickness and surface area) of seven bilateral subcortical structures were quantified. The patients and HCs were then compared vertex-wise, and shape anomalies were co-located with brain neurotransmitter profiles. We found widespread morphological alterations in GGE and prominent disruptions in the thalamus, putamen, and hippocampus. Shape area dilations were observed in the bilateral ventral, medial, and right dorsal thalamus, as well as the bilateral lateral putamen. We found that the shape area deviation pattern was spatially correlated with the norepinephrine transporter and nicotinic acetylcholine (Ach) receptor (α <subscript>4</subscript> β <subscript>2</subscript> ) profiles, but a distinct association was seen in the muscarinic Ach receptor (M <subscript>1</subscript> ). The findings provided a comprehensive picture of subcortical morphological disruptions in GGE, and further characterized the associated molecular mechanisms. This information may increase our understanding of the pathophysiology of GGE.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Male
Adult
Young Adult
Magnetic Resonance Imaging
Thalamus pathology
Thalamus diagnostic imaging
Thalamus metabolism
Brain pathology
Brain diagnostic imaging
Adolescent
Putamen pathology
Putamen diagnostic imaging
Putamen metabolism
Case-Control Studies
Hippocampus pathology
Epilepsy, Generalized pathology
Epilepsy, Generalized physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2399-3642
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Communications biology
- Publication Type :
- Academic Journal
- Accession number :
- 39164447
- Full Text :
- https://doi.org/10.1038/s42003-024-06726-0