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Admissions for posttransplant lymphoproliferative disorder: a 9-year longitudinal analysis of the National (Nationwide) Inpatient Sample.

Authors :
El-Amir Z
Jamil A
Solanki D
Mansuri U
Mathew M
Singh J
Aslam S
Akram H
Mandal S
Kichloo A
Source :
Proceedings (Baylor University. Medical Center) [Proc (Bayl Univ Med Cent)] 2024 Jul 11; Vol. 37 (5), pp. 804-812. Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).
Publication Year :
2024

Abstract

Background: Posttransplant lymphoproliferative disorder (PTLD), a term that encompasses a wide array of malignancies that occur after transplant, can be one of the most devastating transplant complications. While there have been major advancements in care, especially after the landmark PTLD-1 trial in 2012, there is a paucity of information on hospitalizations for PTLD and the changes in hospitalizations over time.<br />Methods: This retrospective cohort study used the National Inpatient Sample to identify hospitalizations for PTLD that occurred between 2009 and 2018. We extracted data for hospitalizations with a primary or secondary diagnosis of PTLD and examined a range of variables, including age, gender, race, hospital type, hospital location, and disposition status. We also collected data on hospital region, median household income, insurance status, and bed size.<br />Results: There was a statistically significant increase in the number of hospitalizations from 2009 to 2019 and an increasing rate of hospitalizations over the study period. Hypertension, electrolyte imbalances, renal failure, and anemia were among the most common comorbidities. We found an increased mortality rate, but this was not statistically significant.<br />Conclusion: Our study provides insight into the changes in hospitalizations for PTLD over nearly a decade, showing an increase in hospitalizations and reports of comorbidities.<br />Competing Interests: The authors report no funding or conflicts of interest.<br /> (Copyright © 2024 Baylor University Medical Center.)

Details

Language :
English
ISSN :
0899-8280
Volume :
37
Issue :
5
Database :
MEDLINE
Journal :
Proceedings (Baylor University. Medical Center)
Publication Type :
Academic Journal
Accession number :
39165820
Full Text :
https://doi.org/10.1080/08998280.2024.2375688