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Case report: Spontaneous improvement and treatment considerations in leukoencephalopathy with calcifications and cysts.
- Source :
-
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2024 Oct; Vol. 245, pp. 108517. Date of Electronic Publication: 2024 Aug 18. - Publication Year :
- 2024
-
Abstract
- We present the case of a patient with leukoencephalopathy with calcifications and cysts (LCC), who experienced progressive severe hemiparesis despite multiple neurosurgical interventions of a large contralateral cyst. Bevacizumab was proposed as an ultimate treatment option based on prior case reports. While awaiting reimbursement approval for bevacizumab, major improvement occurred in both clinical and radiological disease manifestations. The disease course of LCC is variable and unpredictable; neurosurgical treatment should be reserved for severe and progressive neurological deficits. Bevacizumab has been reported as a promising alternative treatment option. Importantly, in our case the observed clinical improvement would have been attributed to the effects of bevacizumab, if started when requested. Our case underscores the need for a natural history study for LCC and the necessity of validating treatment efficacy by systematic evaluation through appropriate clinical trials rather than relying on anecdotal evidence from published case reports.<br />Competing Interests: Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Cysts surgery
Cysts complications
Cysts diagnostic imaging
Male
Bevacizumab therapeutic use
Middle Aged
Magnetic Resonance Imaging
Female
Central Nervous System Cysts surgery
Central Nervous System Cysts complications
Central Nervous System Cysts diagnostic imaging
Central Nervous System Cysts drug therapy
Leukoencephalopathies diagnostic imaging
Leukoencephalopathies complications
Leukoencephalopathies drug therapy
Calcinosis diagnostic imaging
Calcinosis drug therapy
Calcinosis surgery
Calcinosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6968
- Volume :
- 245
- Database :
- MEDLINE
- Journal :
- Clinical neurology and neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 39173493
- Full Text :
- https://doi.org/10.1016/j.clineuro.2024.108517