Back to Search
Start Over
Structure of anellovirus-like particles reveal a mechanism for immune evasion.
- Source :
-
Nature communications [Nat Commun] 2024 Aug 22; Vol. 15 (1), pp. 7219. Date of Electronic Publication: 2024 Aug 22. - Publication Year :
- 2024
-
Abstract
- Anelloviruses are nonpathogenic viruses that comprise a major portion of the human virome. Despite being ubiquitous in the human population, anelloviruses (ANVs) remain poorly understood. Basic features of the virus, such as the identity of its capsid protein and the structure of the viral particle, have been unclear until now. Here, we use cryogenic electron microscopy to describe the first structure of an ANV-like particle. The particle, formed by 60 jelly roll domain-containing ANV capsid proteins, forms an icosahedral particle core from which spike domains extend to form a salient part of the particle surface. The spike domains come together around the 5-fold symmetry axis to form crown-like features. The base of the spike domain, the P1 subdomain, shares some sequence conservation between ANV strains while a hypervariable region, forming the P2 subdomain, is at the spike domain apex. We propose that this structure renders the particle less susceptible to antibody neutralization by hiding vulnerable conserved domains while exposing highly diverse epitopes as immunological decoys, thereby contributing to the immune evasion properties of anelloviruses. These results shed light on the structure of anelloviruses and provide a framework to understand their interactions with the immune system.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Anelloviridae genetics
Anelloviridae immunology
Models, Molecular
Protein Domains
Epitopes immunology
Epitopes chemistry
Amino Acid Sequence
Cryoelectron Microscopy
Capsid Proteins chemistry
Capsid Proteins immunology
Capsid Proteins ultrastructure
Virion ultrastructure
Virion immunology
Immune Evasion
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 39174507
- Full Text :
- https://doi.org/10.1038/s41467-024-51064-8