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Analysis of the function, mechanism and clinical application prospect of TRPS1, a new marker for breast cancer.
- Source :
-
Gene [Gene] 2025 Jan 10; Vol. 932, pp. 148880. Date of Electronic Publication: 2024 Aug 23. - Publication Year :
- 2025
-
Abstract
- It has been discovered that Trichorhinophalangeal Syndrome-1 (TRPS1), a novel member of the GATA transcription factor family, participates in both normal physiological processes and the development of numerous diseases. Recently, TRPS1 has been identified as a new biomarker to aid in cancer diagnosis and is very common in breast cancer (BC), especially in triple-negative breast cancer (TNBC). In this review, we discussed the structure and function of TRPS1 in various normal cells, focused on its role in tumorigenesis and tumor development, and summarize the research status of TRPS1 in the occurrence and development of BC. We also analyzed the potential use of TRPS1 in guiding clinically personalized precision treatment and the development of targeted drugs.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Female
Triple Negative Breast Neoplasms genetics
Triple Negative Breast Neoplasms metabolism
Gene Expression Regulation, Neoplastic
Carcinogenesis genetics
Carcinogenesis metabolism
Animals
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Transcription Factors genetics
Transcription Factors metabolism
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Repressor Proteins genetics
Repressor Proteins metabolism
Breast Neoplasms genetics
Breast Neoplasms diagnosis
Breast Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0038
- Volume :
- 932
- Database :
- MEDLINE
- Journal :
- Gene
- Publication Type :
- Academic Journal
- Accession number :
- 39181273
- Full Text :
- https://doi.org/10.1016/j.gene.2024.148880