Back to Search
Start Over
Glycerol Handling in Paired Visceral and Subcutaneous Adipose Tissues in Women with Normal Weight and Upper-Body Obesity.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 Aug 19; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 19. - Publication Year :
- 2024
-
Abstract
- In adipose tissue, reduced expression of the glycerol channel aquaporin 7 (AQP7) has been associated with increased accumulation of triglyceride. The present study determines the relative protein abundances of lipolytic enzymes, AQP7, and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in paired mesenteric and omental visceral adipose tissue (VAT) and abdominal and femoral subcutaneous adipose tissue (SAT) in women with either normal weight or upper-body obesity. No differences in the expression of hormone-sensitive lipase (HSL) or AQP7 were found between the two groups in the four depots. The expression of adipocyte triglyceride lipase (ATGL) and HSL were higher in omental VAT and femoral SAT than in mesenteric VAT in both groups of women. Similarly, AQP7 expression was higher in omental VAT than in mesenteric VAT. The expression of PEPCK-C was lower in omental VAT than in femoral SAT. No correlation between the expression of AQP7 and the mean adipocyte size was observed; however, the expression of PEPCK-C positively correlated with the mean adipocyte size. In conclusion, a depot-specific protein expression pattern was found for ATGL, HSL, AQP7, and PEPCK-C. The expression pattern supports that the regulation of AQP7 protein expression is at least in part linked to the lipolytic rate. Furthermore, the results support that the synthesis of glycerol-3-phosphate via glyceroneogenesis contributes to regulating triglyceride accumulation in white adipose tissue in women.
- Subjects :
- Humans
Female
Adult
Middle Aged
Lipolysis
Sterol Esterase metabolism
Sterol Esterase genetics
Lipase metabolism
Lipase genetics
Phosphoenolpyruvate Carboxykinase (ATP) metabolism
Phosphoenolpyruvate Carboxykinase (ATP) genetics
Adipocytes metabolism
Triglycerides metabolism
Acyltransferases
Subcutaneous Fat metabolism
Aquaporins metabolism
Aquaporins genetics
Glycerol metabolism
Intra-Abdominal Fat metabolism
Obesity metabolism
Obesity pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 39201693
- Full Text :
- https://doi.org/10.3390/ijms25169008