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Polymeric Mixed Micelle-Loaded Hydrogel for the Ocular Delivery of Fexofenadine for Treating Allergic Conjunctivitis.
- Source :
-
Polymers [Polymers (Basel)] 2024 Aug 07; Vol. 16 (16). Date of Electronic Publication: 2024 Aug 07. - Publication Year :
- 2024
-
Abstract
- This study was designed to formulate a polymeric mixed micelle (PMM) formulation to sustainably release fexofenadine (FEX) to treat allergic conjunctivitis effectively. A 3 <superscript>2</superscript> factorial design was employed where the studied factors were PL90G amount (X <subscript>1</subscript> ) and Pluronic (F127 and P123) mixture ratio (X <subscript>2</subscript> ), and the dependent variables were entrapment efficacy (EE, Y <subscript>1</subscript> , %), particle size (PS, Y <subscript>2</subscript> , nm), zeta potential (ZP, Y <subscript>3</subscript> , mV), and the percent of drug released after 6 h (Q6h, Y <subscript>4</subscript> , %). The optimized formula was blended with a hydrogel base to develop an FEX-PMM hydrogel, where the safety and efficiency of this hydrogel were evaluated using in vivo studies. The EE% of FEX-PMM ranged from 62.15 ± 2.75 to 90.25 ± 1.48%, the PS from 291.35 ± 6.43 to 467.95 ± 3.60 nm, the ZP from -5.41 ± 0.12 to -9.23 ± 0.23 mV, and the Q6h from 50.27 ± 1.11 to 95.38 ± 0.92%. The Draize test results confirmed the safety of the FEX-PMM hydrogel. Furthermore, the FEX-PMM hydrogel showed rapid recovery in animals with induced allergic conjunctivitis compared to the free drug hydrogel. These results assure PMM's capability to deliver FEX to the conjunctival surface in a sustained pattern, consequently achieving better therapeutic outcomes.
Details
- Language :
- English
- ISSN :
- 2073-4360
- Volume :
- 16
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Polymers
- Publication Type :
- Academic Journal
- Accession number :
- 39204460
- Full Text :
- https://doi.org/10.3390/polym16162240