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[Severe complicated malaria caused by Plasmodium falciparum in a female traveler returning from Zanzibar].
- Source :
-
Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 2024 Sep; Vol. 149 (18), pp. 1090-1093. Date of Electronic Publication: 2024 Aug 29. - Publication Year :
- 2024
-
Abstract
- Medical History: A 25-year-old female outpatient presenting with fever and micro-hematuria was treated for urinary tract infection. Her condition worsened over 3 days at home. After experiencing multiple falls caused by leg weakness and mental confusion, she was admitted to a hospital with high fever.<br />Diagnostics: Initial laboratory findings showed hemolytic anemia, pancytopenia, and acute kidney injury, suggesting hemolytic uremic syndrome. However, a detailed fever evaluation revealed her recent return from Afrika. This prompted a malaria test, which confirmed Plasmodium falciparum infection with 80 % parasitemia.<br />Therapy and Progress: Despite the quick reduction of parasitemia following treatment with intravenous administered artesunate and oral Artemether-Lumefantrine, her condition worsened, leading to a septic shock. This required renal replacement and kinetic ventilation therapy, as well as blood transfusions due to persistent hemolysis until the laboratory values normalized after 48 days post-admission.<br />Conclusion: The evaluation of fever is often challenging, but most often a detailed patient history is key to early diagnosis and treatment preventing deathly outcomes in severe cases.<br />Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.<br /> (Thieme. All rights reserved.)
- Subjects :
- Adult
Female
Humans
Artemether, Lumefantrine Drug Combination therapeutic use
Artesunate therapeutic use
Plasmodium falciparum isolation & purification
Shock, Septic diagnosis
Shock, Septic parasitology
Shock, Septic therapy
Tanzania
Travel-Related Illness
Antimalarials therapeutic use
Malaria, Falciparum complications
Malaria, Falciparum diagnosis
Malaria, Falciparum therapy
Subjects
Details
- Language :
- German
- ISSN :
- 1439-4413
- Volume :
- 149
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Deutsche medizinische Wochenschrift (1946)
- Publication Type :
- Academic Journal
- Accession number :
- 39208861
- Full Text :
- https://doi.org/10.1055/a-2359-7083