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The prognostic role of remnant cholesterol in Asian menopausal women received percutaneous coronary intervention with acute coronary syndrome.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2024 Aug 30; Vol. 23 (1), pp. 276. Date of Electronic Publication: 2024 Aug 30. - Publication Year :
- 2024
-
Abstract
- Background: Remnant cholesterol (RC) exert a significant influence on atherosclerotic cardiovascular disease development. However, the prognostic implications of RC in menopausal women received percutaneous coronary intervention (PCI) who experiencing acute coronary syndrome (ACS) remain uncertain.<br />Methods: RC was derived by subtracting the sum of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol from the total cholesterol. Kaplan-Meier survival and Cox regression analysis were employed for assessing the correlation between continuous RC levels and composite and individual adverse events in Q1-Q4 quartiles. Receiver operator characteristic (ROC) curves, derived from Cox regression, were employed for analyzing the relationship between RC and both composite and individual adverse events.<br />Results: 1505 consecutive menopausal women who underwent PCI and diagnosed with ACS were included. Kaplan-Meier survival analysis demonstrated a progressive reduction in composite adverse event survival rates across the four groups, observed in both the general population and among diabetic individuals, as RC values increased (Log-rank Pā<ā0.001). The analysis of multivariate Cox regression indicated RC remained independently associated with both composite and individual adverse events. ROC analysis showed that RC enhanced the area under the curve both in total and diabetic populations for composite adverse events.<br />Conclusion: Among menopausal women diagnosed with ACS who underwent PCI, heightened levels of RC were found to be independently correlated with an increased occurrence of adverse events.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Middle Aged
Aged
Prognosis
Kaplan-Meier Estimate
Proportional Hazards Models
ROC Curve
Cholesterol, HDL blood
Asian People
Cholesterol, LDL blood
Risk Factors
Acute Coronary Syndrome blood
Acute Coronary Syndrome therapy
Acute Coronary Syndrome surgery
Acute Coronary Syndrome mortality
Percutaneous Coronary Intervention
Menopause
Cholesterol blood
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 39215317
- Full Text :
- https://doi.org/10.1186/s12944-024-02258-y