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Extreme Reactive Thrombocytosis Caused by Obstructive Nephrolithiasis and Pyelonephritis.
- Source :
-
Clinical medicine & research [Clin Med Res] 2024 Jun; Vol. 22 (2), pp. 112-114. - Publication Year :
- 2024
-
Abstract
- Platelet counts in reactive thrombocytosis rarely exceed 1000 × 10 <superscript>9</superscript> /L. We present the case of a male patient, aged 80 years, with quiescent rheumatoid arthritis who was found to have a platelet count of 1011 × 10 <superscript>9</superscript> /L on routine laboratory testing. The patient was initially asymptomatic but developed leukocytosis to 23.1 × 10 <superscript>9</superscript> /L on hospital day 2. Diagnostic work-up revealed obstructive nephrolithiasis and pyelonephritis, and the thrombocytosis and leukocytosis gradually resolved with empiric antibiotic treatment and ureteral stent placement. Tests for myeloproliferative disorders, including JAK-2V617F mutation, BCR-ABL for chronic myeloid leukemia and acute lymphocytic leukemia, and myeloproliferative neoplasms (MPL/CALR), were negative. Physicians should be aware that in rare cases reactive thrombocytosis can exceed 1000 × 10 <superscript>9</superscript> /L, and that markedly elevated platelet counts in the setting of urinary tract infections may be an early sign of obstructive uropathy.<br /> (Copyright © 2024 Marshfield Clinic Health System.)
Details
- Language :
- English
- ISSN :
- 1554-6179
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical medicine & research
- Publication Type :
- Academic Journal
- Accession number :
- 39231624
- Full Text :
- https://doi.org/10.3121/cmr.2024.1899