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Case report: Ovarian steroid cell tumor with CA72-4 elevated.
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2024 Dec; Vol. 40 (1), pp. 2400943. Date of Electronic Publication: 2024 Sep 10. - Publication Year :
- 2024
-
Abstract
- Ovarian steroid cell tumor, not otherwise specified (SCT-NOS), is a rare subtype of sex cord-stromal tumor, characterized by hirsutism and virilization. There are, however, few tumor markers reported in the tumor. The following is a case report. Six years ago, the patient underwent a left adnexectomy after being diagnosed with a yolk sac tumor. Her serum CA72-4 levels were significantly elevated when she was diagnosed with SCT-NOS. She suffered from hirsutism and oligomenorrhea with long menstrual cycles. SCT-NOS was confirmed by her histopathological examination. When the tumor was diagnosed, serum CA72-4 levels were elevated. Following tumor resection, serum CA72-4 levels returned to the average reference interval. Whole-exome sequencing (WES) was utilized to identify ten mutations in MKI67, TICAM1, CHD3, ARID5B, ERBB4, POLD1, FZR1, MTCP1, TBX3, and CLTC genes.
- Subjects :
- Humans
Female
Adult
Antigens, Tumor-Associated, Carbohydrate blood
Biomarkers, Tumor blood
Biomarkers, Tumor genetics
Ovarian Neoplasms diagnosis
Ovarian Neoplasms genetics
Ovarian Neoplasms surgery
Ovarian Neoplasms pathology
Ovarian Neoplasms blood
Sex Cord-Gonadal Stromal Tumors genetics
Sex Cord-Gonadal Stromal Tumors pathology
Sex Cord-Gonadal Stromal Tumors diagnosis
Sex Cord-Gonadal Stromal Tumors blood
Sex Cord-Gonadal Stromal Tumors surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0766
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 39254063
- Full Text :
- https://doi.org/10.1080/09513590.2024.2400943