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Sulfonyl-acetohydrazide derivatives as juvenile hormone mimics to be insect growth regulators.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107781. Date of Electronic Publication: 2024 Sep 05. - Publication Year :
- 2024
-
Abstract
- The need for targeted pest control strategies has led to the development of juvenile hormone (JH) mimics that selectively disrupt the life cycles of harmful insect species. Present study focuses on the synthesis, characterization and evaluation of sulfonyl-acetohydrazide derivatives (H1-H8) as novel JH mimics on two different insect species, with an emphasis on their insect-specific action. The yellow fever mosquito, Aedes aegypti and cabbage leaf borer, Spodoptera litura, were selected for this investigation. Our results indicate that while these compounds exhibit negligible effects on the development of Aedes aegypti, they demonstrate a potent and specific action against Spodoptera litura. The sulfonyl-acetohydrazide derivatives induced significant developmental abnormalities and increased mortality rates in Spodoptera litura larvae, leading to a marked disruption in their life cycle. Additionally, Density Functional Theory methods were employed to elucidate the electronic structure and corelate the reactivity of the synthesized compounds with the insect growth regulating activity (IGR). The DNA-binding study of synthesized JH analogs has been carried out using UV-vis spectroscopy for toxicity assessment against biomolecule DNA. All the synthesized JH analogs (H1-H8) show IGR action and exhibit better reactivity and reduced toxicity as compared to the commercial in use IGR, pyriproxyfen.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Structure-Activity Relationship
Molecular Structure
Dose-Response Relationship, Drug
Insecticides pharmacology
Insecticides chemistry
Insecticides chemical synthesis
Larva drug effects
Juvenile Hormones pharmacology
Juvenile Hormones chemistry
Juvenile Hormones chemical synthesis
Spodoptera drug effects
Spodoptera growth & development
Hydrazines chemistry
Hydrazines pharmacology
Hydrazines chemical synthesis
Aedes drug effects
Aedes growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 153
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 39255607
- Full Text :
- https://doi.org/10.1016/j.bioorg.2024.107781