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MicroRNAs: pioneering regulators in Alzheimer's disease pathogenesis, diagnosis, and therapy.
- Source :
-
Translational psychiatry [Transl Psychiatry] 2024 Sep 10; Vol. 14 (1), pp. 367. Date of Electronic Publication: 2024 Sep 10. - Publication Year :
- 2024
-
Abstract
- This article delves into Alzheimer's disease (AD), a prevalent neurodegenerative condition primarily affecting the elderly. It is characterized by progressive memory and cognitive impairments, severely disrupting daily life. Recent research highlights the potential involvement of microRNAs in the pathogenesis of AD. MicroRNAs (MiRNAs), short non-coding RNAs comprising 20-24 nucleotides, significantly influence gene regulation by hindering translation or promoting degradation of target genes. This review explores the role of specific miRNAs in AD progression, focusing on their impact on β-amyloid (Aβ) peptide accumulation, intracellular aggregation of hyperphosphorylated tau proteins, mitochondrial dysfunction, neuroinflammation, oxidative stress, and the expression of the APOE4 gene. Our insights contribute to understanding AD's pathology, offering new avenues for identifying diagnostic markers and developing novel therapeutic targets.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Animals
Apolipoprotein E4 genetics
Gene Expression Regulation
Alzheimer Disease genetics
Alzheimer Disease therapy
Alzheimer Disease diagnosis
Alzheimer Disease metabolism
MicroRNAs genetics
Amyloid beta-Peptides metabolism
tau Proteins metabolism
tau Proteins genetics
Oxidative Stress genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2158-3188
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Translational psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 39256358
- Full Text :
- https://doi.org/10.1038/s41398-024-03075-8