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Real-time fMRI neurofeedback modulates induced hallucinations and underlying brain mechanisms.
- Source :
-
Communications biology [Commun Biol] 2024 Sep 11; Vol. 7 (1), pp. 1120. Date of Electronic Publication: 2024 Sep 11. - Publication Year :
- 2024
-
Abstract
- Hallucinations can occur in the healthy population, are clinically relevant and frequent symptoms in many neuropsychiatric conditions, and have been shown to mark disease progression in patients with neurodegenerative disorders where antipsychotic treatment remains challenging. Here, we combine MR-robotics capable of inducing a clinically-relevant hallucination, with real-time fMRI neurofeedback (fMRI-NF) to train healthy individuals to up-regulate a fronto-parietal brain network associated with the robotically-induced hallucination. Over three days, participants learned to modulate occurrences of and transition probabilities to this network, leading to heightened sensitivity to induced hallucinations after training. Moreover, participants who became sensitive and succeeded in fMRI-NF training, showed sustained and specific neural changes after training, characterized by increased hallucination network occurrences during induction and decreased hallucination network occurrences during a matched control condition. These data demonstrate that fMRI-NF modulates specific hallucination network dynamics and highlights the potential of fMRI-NF as a novel antipsychotic treatment in neurodegenerative disorders and schizophrenia.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Adult
Young Adult
Brain Mapping methods
Schizophrenia physiopathology
Schizophrenia diagnostic imaging
Hallucinations physiopathology
Hallucinations diagnostic imaging
Hallucinations therapy
Magnetic Resonance Imaging methods
Neurofeedback methods
Brain diagnostic imaging
Brain physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2399-3642
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Communications biology
- Publication Type :
- Academic Journal
- Accession number :
- 39261559
- Full Text :
- https://doi.org/10.1038/s42003-024-06842-x