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Preparation and osteogenesis of a multiple crosslinking silk fibroin/carboxymethyl chitosan/sodium alginate composite scaffold loading with mesoporous silica/poly (lactic acid-glycolic acid) microspheres.
- Source :
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Journal of biomaterials applications [J Biomater Appl] 2024 Sep 12, pp. 8853282241281439. Date of Electronic Publication: 2024 Sep 12. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
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Abstract
- Large bone defect repair is a striking challenge in orthopedics. Currently, inorganic-organic composite scaffolds are considered as a promising approach to these bone regeneration. Silicon ions (Si <superscript>4+</superscript> ) are bioactive and beneficial to bone regeneration and Si <superscript>4+</superscript> -containing inorganic mesoporous silica (MS) can effectively load drugs for bone repair. To better control the release of drug, we prepared biodegradable MS/PLGA (MP) microspheres. MP loaded organic silk fibroin/carboxymethyl chitosan/sodium alginate (MP/SF/CMCS/SA) composite scaffolds were further constructed by genipin and Ca <superscript>2+</superscript> crosslinking. All MP/SF/CMCS/SA scaffolds had good swelling ability, degradation rate and high porosity. The incorporation of 1% MP significantly enhanced the compressive strength of composite scaffolds. Besides, MP loaded scaffold showed a sustained release of Si <superscript>4+</superscript> and Ca <superscript>2+</superscript> . Moreover, the release rate of rhodamine (a model drug) of MP/SF/CMCS/SA scaffolds was obviously lower than that of MP. When culturing with rat bone marrow mesenchymal stem cells, scaffolds with 1% MP displayed good proliferation, adhesion and enhanced osteogenic differentiation ability. Based on the results above, the addition of 1% MP in SF/CMCS/SA scaffolds is a prospective way for drug release in bone regeneration and is promising for further in vivo bone repair applications.<br />Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Details
- Language :
- English
- ISSN :
- 1530-8022
- Database :
- MEDLINE
- Journal :
- Journal of biomaterials applications
- Publication Type :
- Academic Journal
- Accession number :
- 39264258
- Full Text :
- https://doi.org/10.1177/08853282241281439