Back to Search
Start Over
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury.
- Source :
-
Neuromolecular medicine [Neuromolecular Med] 2024 Sep 12; Vol. 26 (1), pp. 37. Date of Electronic Publication: 2024 Sep 12. - Publication Year :
- 2024
-
Abstract
- As the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmission. Injuries to the optic nerve can occur for various reasons, including trauma, glaucoma, and neurodegenerative diseases. Retinal ganglion cells (RGCs), a type of neurons that extend axons through the optic nerve, can rapidly respond to injury and initiate cell death. Additionally, following optic nerve injury microglia, which serve as markers of neuroinflammation, transition from a resting state to an activated state. The phosphorylation of collapsin response mediator protein2 (CRMP2) in the semaphorin 3A (Sema3A) signalling pathway affects several processes, including axon guidance and neuron regeneration. In this study, we used an optic nerve crush (ONC) mouse model to investigate the effects of suppressing CRMP2 phosphorylation on microglia activation. We found that CRMP2 phosphorylation inhibitor suppressed RGCs loss and promoted neuronal regeneration following ONC. In addition, CRMP2 S522A mutant (CRMP2 KI) mice exhibited decreased microglial activation in both the retina and optic nerve following ONC. These results suggest that inhibiting the phosphorylation of CRMP2 can alleviate the loss of RGCs and microglial activation after optic nerve injury, providing insight into the development of treatments for optical neuropathies and neurodegenerative diseases.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Phosphorylation
Mice
Nerve Crush
Mice, Inbred C57BL
Male
Disease Models, Animal
Mice, Transgenic
Optic Nerve Injuries physiopathology
Optic Nerve Injuries metabolism
Optic Nerve Injuries drug therapy
Microglia metabolism
Microglia drug effects
Nerve Regeneration drug effects
Intercellular Signaling Peptides and Proteins genetics
Nerve Tissue Proteins genetics
Retinal Ganglion Cells drug effects
Retinal Ganglion Cells metabolism
Optic Nerve metabolism
Semaphorin-3A genetics
Semaphorin-3A metabolism
Retina drug effects
Retina metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1174
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuromolecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39266914
- Full Text :
- https://doi.org/10.1007/s12017-024-08805-1