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TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma.
- Source :
-
Cancer discovery [Cancer Discov] 2024 Dec 02; Vol. 14 (12), pp. 2352-2366. - Publication Year :
- 2024
-
Abstract
- Significance: Novel individual biomarkers are needed to guide therapeutic decisions for patients with head and neck cancer. We report for the first time, granulomas of TREM2-expressing multinucleated giant macrophages in keratin-rich tumor niches, as a biomarker of favorable prognosis and developed a deep-learning model to automate its quantification on routinely stained pathological slides.<br /> (©2024 The Authors; Published by the American Association for Cancer Research.)
- Subjects :
- Humans
Prognosis
Giant Cells pathology
Giant Cells metabolism
Membrane Glycoproteins metabolism
Biomarkers, Tumor metabolism
Receptors, Immunologic metabolism
Receptors, Immunologic genetics
Macrophages metabolism
Squamous Cell Carcinoma of Head and Neck metabolism
Squamous Cell Carcinoma of Head and Neck pathology
Squamous Cell Carcinoma of Head and Neck genetics
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms pathology
Head and Neck Neoplasms diagnosis
Head and Neck Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2159-8290
- Volume :
- 14
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cancer discovery
- Publication Type :
- Academic Journal
- Accession number :
- 39270324
- Full Text :
- https://doi.org/10.1158/2159-8290.CD-24-0018