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Supplementation with Fish Oil and Selenium Protects Lipolytic and Thermogenic Depletion of Adipose in Cachectic Mice Treated with an EGFR Inhibitor.
- Source :
-
Cells [Cells] 2024 Sep 04; Vol. 13 (17). Date of Electronic Publication: 2024 Sep 04. - Publication Year :
- 2024
-
Abstract
- Lung cancer and cachexia are the leading causes of cancer-related deaths worldwide. Cachexia is manifested by weight loss and white adipose tissue (WAT) atrophy. Limited nutritional supplements are conducive to lung cancer patients, whereas the underlying mechanisms are poorly understood. In this study, we used a murine cancer cachexia model to investigate the effects of a nutritional formula (NuF) rich in fish oil and selenium yeast as an adjuvant to enhance the drug efficacy of an EGFR inhibitor (Tarceva). In contrast to the healthy control, tumor-bearing mice exhibited severe cachexia symptoms, including tissue wasting, hypoalbuminemia, and a lower food efficiency ratio. Experimentally, Tarceva reduced pEGFR and HIF-1α expression. NuF decreased the expression of pEGFR and HIF-2α, suggesting that Tarceva and NuF act differently in prohibiting tumor growth and subsequent metastasis. NuF blocked LLC tumor-induced PTHrP and expression of thermogenic factor UCP1 and lipolytic enzymes (ATGL and HSL) in WAT. NuF attenuated tumor progression, inhibited PTHrP-induced adipose tissue browning, and maintained adipose tissue integrity by modulating heat shock protein (HSP) 72. Added together, Tarceva in synergy with NuF favorably improves cancer cachexia as well as drug efficacy.
- Subjects :
- Animals
Mice
Mice, Inbred C57BL
Male
Adipose Tissue, White drug effects
Adipose Tissue, White metabolism
Adipose Tissue, White pathology
Adipose Tissue drug effects
Adipose Tissue metabolism
Cachexia drug therapy
Cachexia pathology
Selenium pharmacology
Selenium therapeutic use
Lipolysis drug effects
ErbB Receptors metabolism
ErbB Receptors antagonists & inhibitors
Thermogenesis drug effects
Fish Oils pharmacology
Fish Oils therapeutic use
Dietary Supplements
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 13
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 39273055
- Full Text :
- https://doi.org/10.3390/cells13171485