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Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach.

Authors :
Guido D
Maqoud F
Aloisio M
Mallardi D
Ura B
Gualandi N
Cocca M
Russo F
Source :
International journal of molecular sciences [Int J Mol Sci] 2024 Aug 28; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 28.
Publication Year :
2024

Abstract

Irritable bowel syndrome with diarrhea (IBS-D) is the most prevalent subtype of IBS, characterized by chronic gastrointestinal symptoms in the absence of identifiable pathological findings. This study aims to investigate the molecular mechanisms underlying IBS-D using transcriptomic data. By employing causal network inference methods, we identify key transcriptomic modules associated with IBS-D. Utilizing data from public databases and applying advanced computational techniques, we uncover potential biomarkers and therapeutic targets. Our analysis reveals significant molecular alterations that affect cellular functions, offering new insights into the complex pathophysiology of IBS-D. These findings enhance our understanding of the disease and may foster the development of more effective treatments.

Details

Language :
English
ISSN :
1422-0067
Volume :
25
Issue :
17
Database :
MEDLINE
Journal :
International journal of molecular sciences
Publication Type :
Academic Journal
Accession number :
39273274
Full Text :
https://doi.org/10.3390/ijms25179322