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Diminishing calcifications as a potential predictor of pancreatic ductal adenocarcinoma arising in association with IPMN in patients with chronic pancreatitis.

Authors :
Yasrab M
Rizk RC
Lopez-Ramirez F
Ahmed TM
Blanco A
Javed AA
Chu LC
Fishman EK
Kawamoto S
Source :
Radiology case reports [Radiol Case Rep] 2024 Aug 27; Vol. 19 (11), pp. 5299-5303. Date of Electronic Publication: 2024 Aug 27 (Print Publication: 2024).
Publication Year :
2024

Abstract

Chronic pancreatitis (CP) is a progressive benign fibroinflammatory condition involving repeated episodes of pancreatic inflammation, which lead to fibrotic tissue replacement and subsequent pancreatic insufficiency. A lifetime risk of developing pancreatic ductal adenocarcinoma (PDAC) in patients with chronic pancreatitis is reported to be 1.5%-4%. However, diagnosis of PDAC in patients with CP can be challenging, in part due to overlapping imaging features. In rare instances, pancreatic parenchymal calcifications that are typically associated with chronic pancreatitis may diminish in the case of a developing PDAC. In this article, we present a patient with chronic pancreatitis in whom calcifications decreased at the time of pancreatic ductal adenocarcinoma diagnosis, as compared to prior CT imaging. The unique imaging features of "diminishing calcifications" associated with a hypoattenuating lesion can potentially be a useful sign of pancreatic ductal adenocarcinoma and may aid in early diagnosis and prompt treatment intervention.<br /> (© 2024 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)

Details

Language :
English
ISSN :
1930-0433
Volume :
19
Issue :
11
Database :
MEDLINE
Journal :
Radiology case reports
Publication Type :
Academic Journal
Accession number :
39280750
Full Text :
https://doi.org/10.1016/j.radcr.2024.08.018