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Multi-Chambered Core/Shell Supraparticles for Real-Time, Full-Time Diagnosis and Treatment Integration of Tumors.

Authors :
Kong D
Zheng X
Ding K
Zhong R
Zhang Z
Wang Q
Dong C
Zheng Z
Li X
Weng J
Zhou S
Source :
Advanced healthcare materials [Adv Healthc Mater] 2024 Sep 18, pp. e2401749. Date of Electronic Publication: 2024 Sep 18.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

To a certain extent, theranostic nanoplatforms promote tumor treatment efficiency. However, timely monitoring of the critical stages and signal sustainability of the entire process is challenging. In this study, multi-chambered core/shell magnetic nanoparticles (MC-MNPs) as drug and imaging agent multi-loaded nanocarriers with a synergistic release function are reported. Supraparticles with stable chambers are formed by the supercooling self-assembly of several core/shell magnetic nanoparticles composed of amphiphilic copolymers as the core and hydrophilic magnetic iron oxide nanoparticles as the shell. Desalinized doxorubicin and coumarin 6 are stored in different cavities of nanocarriers, and chitosan is used as an outer encapsulation layer. Based on their construction properties, MC-MNPs can exhibit gradient-degraded and steady-released controllability in the tumor environment. Furthermore, real-time accumulation situations and full-time diagnostic signals of nanocarriers are thoroughly demonstrated using fluorescence imaging and T <subscript>2</subscript> -weighted magnetic resonance imaging before and after magnetic hyperthermia in targeted tumors under an alternating magnetic field. Thus, MC-MNPs as theranostic nanocarriers exhibit great potential for the timely monitoring and full-time guidance of tumor treatment.<br /> (© 2024 Wiley‐VCH GmbH.)

Details

Language :
English
ISSN :
2192-2659
Database :
MEDLINE
Journal :
Advanced healthcare materials
Publication Type :
Academic Journal
Accession number :
39291882
Full Text :
https://doi.org/10.1002/adhm.202401749