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Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region.

Authors :
Naveca FG
Almeida TAP
Souza V
Nascimento V
Silva D
Nascimento F
Mejía M
Oliveira YS
Rocha L
Xavier N
Lopes J
Maito R
Meneses C
Amorim T
Fé L
Camelo FS
Silva SCA
Melo AX
Fernandes LG
Oliveira MAA
Arcanjo AR
Araújo G
André Júnior W
Carvalho RLC
Rodrigues R
Albuquerque S
Mattos C
Silva C
Linhares A
Rodrigues T
Mariscal F
Morais MA
Presibella MM
Marques NFQ
Paiva A
Ribeiro K
Vieira D
Queiroz JADS
Passos-Silva AM
Abdalla L
Santos JH
Figueiredo RMP
Cruz ACR
Casseb LN
Chiang JO
Frutuoso LV
Rossi A
Freitas L
Campos TL
Wallau GL
Moreira E
Lins Neto RD
Alexander LW
Sun Y
Filippis AMB
Gräf T
Arantes I
Bento AI
Delatorre E
Bello G
Source :
Nature medicine [Nat Med] 2024 Dec; Vol. 30 (12), pp. 3509-3521. Date of Electronic Publication: 2024 Sep 18.
Publication Year :
2024

Abstract

The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. In this study, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia and Ecuador (2008-2021). The novel reassortant likely emerged in the Amazonas state between 2010 and 2014 and spread through long-range dispersion events during the second half of the 2010s. Phylodynamics reconstructions showed that the current OROV spread was driven mainly by short-range (< 2 km) movements consistent with the flight range of vectors. Nevertheless, a substantial proportion (22%) of long-range (>10 km) OROV migrations were also detected, consistent with viral dispersion by humans. Our data provide a view of the unprecedented spread and evolution of OROV in the Brazilian western Amazon region.<br />Competing Interests: Competing interests: All authors declare that no conflicts of interest exist.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)

Details

Language :
English
ISSN :
1546-170X
Volume :
30
Issue :
12
Database :
MEDLINE
Journal :
Nature medicine
Publication Type :
Academic Journal
Accession number :
39293488
Full Text :
https://doi.org/10.1038/s41591-024-03300-3