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Assessment of haemolysis models for a positive-displacement total artificial heart.
Assessment of haemolysis models for a positive-displacement total artificial heart.
- Source :
-
The International journal of artificial organs [Int J Artif Organs] 2024 Aug; Vol. 47 (8), pp. 570-581. Date of Electronic Publication: 2024 Sep 19. - Publication Year :
- 2024
-
Abstract
- The assessment and reduction of haemolysis within mechanical circulatory support (MCS) remains a concern with regard to device safety and regulatory approval. Numerical methods for predicting haemolysis have typically been applied to rotary MCS devices and the extent to which these methods apply to positive-displacement MCS is unclear. The aim of this study was to evaluate the suitability of these methods for assessing haemolysis in positive-displacement blood pumps. Eulerian scalar-transport and Lagrangian particle-tracking approaches derived from the shear-based power-law relationship were used to calculate haemolysis in a computational fluid dynamics model of the Realheart total artificial heart. A range of power-law constants and their effect on simulated haemolysis were also investigated. Both Eulerian and Lagrangian methods identified the same key mechanism of haemolysis: leakage flow through the bileaflet valves. Whilst the magnitude of haemolysis varied with different power-law constants, the method of haemolysis generation remained consistent. The Eulerian method was more robust and reliable at identifying sites of haemolysis generation, as it was able to capture the persistent leakage flow throughout the entire pumping cycle. This study paves the way for different positive-displacement MCS devices to be compared across different operating conditions, enabling the optimisation of these pumps for improved patient outcomes.<br />Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: S.F.Z, A.N., T.F. and I.L.P. are employees of or consultants to and/or shareholders of Scandinavian Real Heart AB. J.B., A.N.C. and K.H.F. declare no potential conflicts of interest.
Details
- Language :
- English
- ISSN :
- 1724-6040
- Volume :
- 47
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The International journal of artificial organs
- Publication Type :
- Academic Journal
- Accession number :
- 39297328
- Full Text :
- https://doi.org/10.1177/03913988241267797