Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?

Authors :: Omura SN
Nureki O
Source :: Cell [Cell] 2024 Sep 19; Vol. 187 (19), pp. 5220-5222.
Publication Year :: 2024
Abstract: Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural diversity of Fanzors and identify key features shared with TnpB and Cas12 proteins, providing a comprehensive perspective on their molecular function and evolution.<br />Competing Interests: Declaration of interests O.N. is a co-founder, board member, and scientific advisor of Curreio.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Subjects :: Eukaryota genetics
RNA, Guide, CRISPR-Cas Systems genetics
RNA, Guide, CRISPR-Cas Systems metabolism
CRISPR-Associated Proteins metabolism
CRISPR-Associated Proteins genetics
DNA genetics
DNA metabolism
Endodeoxyribonucleases metabolism
Endodeoxyribonucleases genetics
Humans
CRISPR-Cas Systems genetics

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