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Lacticaseibacillus rhamnosus KY16 Improves Depression by Promoting Intestinal Secretion of 5-HTP and Altering the Gut Microbiota.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Oct 02; Vol. 72 (39), pp. 21560-21573. Date of Electronic Publication: 2024 Sep 23. - Publication Year :
- 2024
-
Abstract
- Increasing research suggests a connection between gut microbiota and depressive disorders. Targeted changes to the intestinal flora may contribute to alleviating anxiety and depression. This study aimed to identify probiotics that could attenuate stress-induced abnormal behavior and explore potential mechanisms. The administration of LR.KY16 significantly reduced stress-induced abnormal behaviors and physiological dysfunction. The mechanism may be via regulating the structure of the intestinal microbiota in mice, increasing the abundance of Akkermansia muciniphila , prompting enterochromaffin cells to secrete 5-HTP in the gut, which enters the brain through the bloodstream and promotes the synthesis of 5-HT in the brain, and then activates brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) through the 5-HT1A receptor. In addition, LR.KY16 also increased the expression of claudin-7, occludin, and zonula occludens-1 (ZO-1) in the colon, inhibited microglial M1 polarization, and inhibited systemic inflammation.
- Subjects :
- Animals
Mice
Male
Humans
Serotonin metabolism
Brain-Derived Neurotrophic Factor metabolism
Brain-Derived Neurotrophic Factor genetics
Akkermansia
Intestines microbiology
Intestinal Mucosa metabolism
Gastrointestinal Microbiome drug effects
Probiotics administration & dosage
Probiotics pharmacology
Depression metabolism
Depression drug therapy
Depression microbiology
Lacticaseibacillus rhamnosus metabolism
Mice, Inbred C57BL
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 72
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 39311539
- Full Text :
- https://doi.org/10.1021/acs.jafc.4c03870