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The role of C-reactive protein as a risk marker of postoperative delirium in older hip fracture patients: a prospective cohort study.
The role of C-reactive protein as a risk marker of postoperative delirium in older hip fracture patients: a prospective cohort study.
- Source :
-
European geriatric medicine [Eur Geriatr Med] 2024 Dec; Vol. 15 (6), pp. 1929-1935. Date of Electronic Publication: 2024 Sep 24. - Publication Year :
- 2024
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Abstract
- Purpose: Postoperative delirium (POD) is a common and serious neuropsychiatric syndrome that leads to higher morbidity and mortality. We investigated the association between serum C-reactive protein (CRP) and the occurrence of POD in older hip fracture patients, and whether CRP predicted POD better than a clinical model.<br />Methods: Patients aged ≥ 75 years admitted for surgical repair of an acute hip fracture were recruited. We compared serum CRP levels between patients with and without POD.<br />Results: Sixty patients were included, of whom 21 (35%) developed POD. Serum CRP levels were significantly higher in patients who developed delirium (p = 0.011). In a multiple regression model including clinical variables and CRP, cognitive impairment (p = 0.003) and infection (p = 0.001) were the best predictors of POD.<br />Conclusions: Although higher levels of serum CRP were significantly associated with POD in older hip fracture patients, pre-existing cognitive impairment and infections were the most important risk factors for POD.<br />Competing Interests: Declarations. Conflict of interest: The authors declare they have no conflict of interest. Ethical approval: Ethical approval was agreed by the Ethical Comittee of the Institution. Informed consent: Informed consent was obtained from all patients prior to all surgical procedures.<br /> (© 2024. The Author(s), under exclusive licence to European Geriatric Medicine Society.)
- Subjects :
- Humans
Male
Female
Aged
Aged, 80 and over
Prospective Studies
Risk Factors
Cognitive Dysfunction blood
Cognitive Dysfunction etiology
C-Reactive Protein analysis
C-Reactive Protein metabolism
Hip Fractures surgery
Hip Fractures blood
Hip Fractures complications
Delirium blood
Delirium etiology
Delirium epidemiology
Postoperative Complications blood
Postoperative Complications epidemiology
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 1878-7649
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European geriatric medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39316273
- Full Text :
- https://doi.org/10.1007/s41999-024-01046-2