The dynamics of the metastatic niche: Lung alveolar type 2 cell reprogramming and cancer cell stemness.

Authors :: Leiwe M
Asselin-Labat ML
Source :: Developmental cell [Dev Cell] 2024 Sep 23; Vol. 59 (18), pp. 2393-2395.
Publication Year :: 2024
Abstract: The complex cellular interactions supporting metastasis formation remain incompletely understood. In this issue of Developmental Cell, Rodrigues et al. describe a positive feedback loop within the lung metastatic niche, whereby disseminated cancer cells promote the multilineage potential of alveolar type 2 cells, favoring cancer cell stemness and metastasis initiation.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Subjects :: Humans
Alveolar Epithelial Cells metabolism
Alveolar Epithelial Cells pathology
Animals
Tumor Microenvironment
Stem Cell Niche
Cellular Reprogramming
Lung Neoplasms pathology
Lung Neoplasms secondary
Neoplastic Stem Cells pathology
Neoplastic Stem Cells metabolism
Neoplasm Metastasis pathology

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